ADPRS

Across TCGA pan-cancer cohorts, ADPRS RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ADPRS data layer compared with 2 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher ADPRS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ADPRS expression acts as an unfavorable survival marker, although some lineages such as CHOL and ESCA show a favorable association.

LIHC, KICH, and ACC are the cancer types where ADPRS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.588	0.773	<.001	98	view →
KICH	DFS	Median	III,IV	0.355	1.000	.001	81	view →
ACC	DFS	Quartile	All	0.175	0.772	.001	56	view →
LGG	DFS	Median	All	0.616	0.862	<.001	54	view →
UCEC	DFS	Tertile	All	0.837	0.929	.004	30	view →
CHOL	DFS	Median	III,IV	0.647	0.127	.006	22	view →
ESCA	DFS	Tertile	All	0.857	0.281	.013	15	view →
PAAD	DFS	Quartile	All	0.382	0.550	.015	13	view →
GBM	OS	Median	All	0.221	0.311	.028	12	view →
KIRP	OS	Median	All	0.811	0.957	.028	9	view →
STAD	DFS	Tertile	IV	0.148	0.805	.028	9	view →
SARC	DFS	Median	All	0.383	0.575	.011	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ADPRS–LIHC (OS)

Open the LIHC breakdown →