ADPRM

Across TCGA patient cohorts, ADPRM mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADPRM-associated genes across cancer lineages are Tuberin, Cyclin-E2, and Shc_pY317. Each is linked with ADPRM in more than 1 cancer types. Because this analysis shows association rather than direction, both ADPRM-to-partner and partner-to-ADPRM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tuberin grouped by ADPRM-low versus ADPRM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADPRM→partner) and Y-score (partner→ADPRM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Tuberin →	+0.430	+2.817	.005	.036	3	1
UCEC	Cyclin-E2 →	+0.199	+3.000	.041	.037	3	1
UCEC	Shc_pY317 →	-0.225	-3.000	.010	.037	2	1
UCEC	VHL →	-1.333	-3.000	<.001	.036	2	1
UCEC	4E-BP1 →	+0.535	+3.000	<.001	.037	2	1
UCEC	Di-Ras3 →	-0.260	-3.000	.002	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Tuberin by ADPRM expression — UCEC

Explore this box plot interactively →