ADORA3

Across TCGA cell cohorts, ADORA3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,048 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADORA3-associated GO terms across cancer lineages are Regulation of TOR signaling, Inner ear development, and Xenophagy. Each is linked with ADORA3 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADORA3-to-partner and partner-to-ADORA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of TOR signaling grouped by ADORA3-low versus ADORA3-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADORA3→partner) and Y-score (partner→ADORA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of TOR signaling →	+0.028	+0.051	<.001	.002	3	5
OESOPHAGUS	Inner ear development →	+0.038	+0.029	.009	.008	3	3
OESOPHAGUS	Xenophagy →	+0.135	+0.043	.003	.006	3	3
BLOOD_Lymphoma	Negative regulation of type I interferon production →	+0.050	+0.755	.002	.007	3	3
LUNG_NSCLC_LUAD	Regulation of platelet-derived growth factor receptor signaling pathway →	+0.074	+0.024	.004	.001	3	3
UPPER_AERODIGESTIVE_TRACT	Regulation of response to cytokine stimulus →	+0.057	+0.022	.005	.005	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,048 associations by consensus.

Regulation of TOR signaling by ADORA3 expression — CNS

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