ADORA3

Across TCGA cell cohorts, ADORA3 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. CNS shows the largest number of these associations.

The most reproducible ADORA3-associated genes across cancer lineages are NKX2-4, KCNA5, and CDX4. Each is linked with ADORA3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADORA3-to-partner and partner-to-ADORA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NKX2-4 grouped by ADORA3-low versus ADORA3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADORA3→partner) and Y-score (partner→ADORA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NKX2-4 →	+0.570	+3.843	.004	.007	3	1
CNS	KCNA5 →	+0.048	+3.832	<.001	.005	3	1
CNS	CDX4 →	+0.008	+4.772	<.001	.002	3	1
CNS	OR4D1 →	+0.048	+3.874	<.001	.006	3	1
CNS	CRCT1 →	+0.567	+3.643	.001	.007	3	1
CNS	PTCRA →	+0.166	+3.874	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

NKX2-4 by ADORA3 expression — CNS

Explore this box plot interactively →