ADORA2B

Across TCGA patient cohorts, ADORA2B mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADORA2B-associated genes across cancer lineages are MAPK_pT202_Y204, MEK1_p_S217_S221, and RAD51. Each is linked with ADORA2B in more than 1 cancer types. Because this analysis shows association rather than direction, both ADORA2B-to-partner and partner-to-ADORA2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by ADORA2B-low versus ADORA2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADORA2B→partner) and Y-score (partner→ADORA2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.749	-3.000	.003	.036	3	1
UCEC	MEK1_p_S217_S221 →	-0.399	-3.169	.007	.020	3	1
UCEC	RAD51 →	+0.204	+3.169	.007	.020	3	1
UCEC	Shc_pY317 →	-0.270	-3.169	.001	.019	3	1
UCEC	AR →	-0.559	-3.169	.006	.020	3	1
UCEC	ATM →	-0.815	-3.169	.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MAPK_pT202_Y204 by ADORA2B expression — UCEC

Explore this box plot interactively →