ADORA2A-AS1

Across TCGA pan-cancer cohorts, ADORA2A-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ADORA2A-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher ADORA2A-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ADORA2A-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, SKCM, and KIRP are the cancer types where ADORA2A-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.733	0.528	<.001	124	view →
SKCM	DFS	Tertile	All	0.717	0.513	<.001	95	view →
KIRP	OS	Median	All	1.000	0.542	<.001	94	view →
HNSC	DFS	Quartile	All	0.832	0.641	.001	57	view →
CHOL	DFS	Median	II,III,IV	0.121	0.626	.002	43	view →
THYM	DFS	Median	II,III,IV	0.924	0.532	.001	35	view →
READ	DFS	Tertile	III,IV	0.847	0.588	.009	28	view →
ACC	DFS	Median	All	0.333	0.715	.001	21	view →
UCS	DFS	Quartile	III,IV	0.520	0.152	.012	20	view →
DLBC	DFS	Median	All	0.629	1.000	.017	20	view →
LUAD	DFS	Tertile	IV	0.367	1.000	.014	18	view →
UVM	OS	Median	II,III,IV	0.904	0.368	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ADORA2A-AS1–KIRC (OS)

Open the KIRC breakdown →