ADORA1

Across TCGA patient cohorts, ADORA1 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADORA1-associated genes across cancer lineages are STAT3_pY705, eEF2, and ERK2. Each is linked with ADORA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADORA1-to-partner and partner-to-ADORA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by ADORA1-low versus ADORA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADORA1→partner) and Y-score (partner→ADORA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.381	-2.459	<.001	.018	3	2
UCEC	eEF2 →	+0.350	+1.807	.017	.027	3	1
UCEC	ERK2 →	+0.204	+1.807	.010	.027	3	1
UCEC	Ku80 →	+0.204	+1.820	.036	.016	3	1
UCEC	mTOR_pS2448 →	-0.147	-2.439	.017	.019	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.542	-2.459	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

STAT3_pY705 by ADORA1 expression — UCEC

Explore this box plot interactively →