ADO

Across TCGA pan-cancer cohorts, ADO mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of ADO’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ADO mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ADO is over-expressed in tumor, although a few such as COAD and PDAC show the opposite, repressed pattern.

COAD, HNSC, and PDAC are the cancer types where ADO tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADO mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	All	−0.240	<.001	8	view →
HNSC	All	IV	+0.180	.001	8	view →
PDAC	All	All	−0.182	.002	5	view →
CCRCC	All	All	−0.077	.001	3	view →
OV	All	All	−0.469	.001	2	view →
LUAD	Female	III,IV	−0.203	.015	2	view →
LSCC	All	II,III,IV	−0.075	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

ADO–COAD

Open the COAD breakdown →