ADO

Across TCGA cell cohorts, ADO RNA expression is significantly associated with the go_rna of many other GO terms, with 3,343 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADO-associated GO terms across cancer lineages are Positive regulation of mitochondrial ATP synthesis coupled electron transport, Nucleotide-excision repair, and Protein localization to non-motile cilium. Each is linked with ADO in more than 10 cancer types. Because this analysis shows association rather than direction, both ADO-to-partner and partner-to-ADO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitochondrial ATP synthesis coupled electron transport grouped by ADO-low versus ADO-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADO→partner) and Y-score (partner→ADO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.091	+0.605	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Nucleotide-excision repair →	+0.082	+0.681	.003	.007	3	10
STOMACH	Protein localization to non-motile cilium →	+0.083	+0.684	<.001	.009	3	10
LARGE_INTESTINE	Positive regulation of organelle assembly →	+0.042	+0.419	.003	.009	3	9
LIVER	Subtelomeric heterochromatin formation →	+0.098	+0.948	<.001	<.001	3	9
LUNG_NSCLC_LUSC	Heterochromatin formation →	+0.060	+0.528	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,343 associations by consensus.

Positive regulation of mitochondrial ATP synthesis coupled electron transport by ADO expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →