ADNP2

Across TCGA patient cohorts, ADNP2 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADNP2-associated genes across cancer lineages are PKC-delta_pS664, C-Raf, and INPP4B. Each is linked with ADNP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADNP2-to-partner and partner-to-ADNP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKC-delta_pS664 grouped by ADNP2-low versus ADNP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADNP2→partner) and Y-score (partner→ADNP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PKC-delta_pS664 →	-0.082	-1.797	.048	.025	3	3
UCEC	C-Raf →	+0.119	+1.440	.016	.024	3	3
UCEC	INPP4B →	-0.245	-2.700	.029	.005	3	2
UCEC	Bak →	+0.187	+1.440	.031	.024	3	2
UCEC	c-Met_pY1235 →	+0.069	+2.070	.007	.001	3	2
UCEC	c-Myc →	-0.211	-3.308	.013	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

PKC-delta_pS664 by ADNP2 expression — UCEC

Explore this box plot interactively →