ADM

Across TCGA pan-cancer cohorts, ADM mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ADM’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where ADM mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ADM is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

LSCC, LUAD, and CCRCC are the cancer types where ADM tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADM mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	Male	All	+0.456	<.001	6	view →
LUAD	Female	III,IV	−1.495	<.001	4	view →
CCRCC	Male	All	+1.057	<.001	4	view →
HNSC	All	III,IV	+1.000	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ADM–LSCC

Open the LSCC breakdown →