ADIRF

Across TCGA pan-cancer cohorts, ADIRF RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of ADIRF’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where ADIRF RNA is repressed in tumor relative to normal tissue. In most cancer types ADIRF is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KICH and BRCA are the cancer types where ADIRF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADIRF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	All	−0.020	.007	3	view →
BRCA	All	II,III,IV	−0.008	.049	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

ADIRF–KICH

Open the KICH breakdown →