ADIPOR2

Across TCGA patient cohorts, ADIPOR2 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADIPOR2-associated genes across cancer lineages are PCNA, EGFR_pY1068, and A-Raf_pS299. Each is linked with ADIPOR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADIPOR2-to-partner and partner-to-ADIPOR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ADIPOR2-low versus ADIPOR2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADIPOR2→partner) and Y-score (partner→ADIPOR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.175	+1.415	.031	.046	3	2
UCEC	EGFR_pY1068 →	-0.259	-3.459	.005	.005	3	1
UCEC	A-Raf_pS299 →	-0.088	-2.321	.048	.005	3	1
UCEC	FOXO3a_pS318_S321 →	-0.101	-1.405	.031	.043	3	1
UCEC	ACC1 →	+0.331	+2.183	.015	.033	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.475	+1.415	.012	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

PCNA by ADIPOR2 expression — UCEC

Explore this box plot interactively →