Across TCGA pan-cancer cohorts, ADI1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ADI1 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ADI1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ADI1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, PDAC, and HNSC are the cancer types where ADI1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Quartile	All	0.652	0.889	.008	30	view →
PDAC	DFS	Tertile	All	0.153	0.445	.007	16	view →
HNSC	OS	Median	All	0.608	0.824	.004	6	view →
LSCC	OS	Median	II,III,IV	1.000	0.905	.021	5	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ADI1 tumor-vs-normal RNA expression · all ADI1 data types