ADHFE1

Across TCGA pan-cancer cohorts, ADHFE1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ADHFE1 data layer compared with 20 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ADHFE1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ADHFE1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, CCRCC, and HNSC are the cancer types where ADHFE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	II,III,IV	1.000	0.383	.022	16	view →
CCRCC	DFS	Median	IV	0.131	0.861	.001	12	view →
HNSC	OS	Median	IV	0.889	0.665	.027	7	view →
LUAD	DFS	Median	All	0.840	0.510	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ADHFE1–PDAC (OS)

Open the PDAC breakdown →