ADHFE1

Across TCGA pan-cancer cohorts, ADHFE1 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of ADHFE1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ADHFE1 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types ADHFE1 is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and LSCC are the cancer types where ADHFE1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ADHFE1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	−1.558	<.001	11	view →
CCRCC	Male	IV	−1.521	<.001	11	view →
LSCC	Male	All	−0.816	<.001	9	view →
LUAD	Female	All	−0.805	<.001	9	view →
PDAC	All	All	−1.363	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

ADHFE1–HNSC

Open the HNSC breakdown →