ADHFE1

Across TCGA patient cohorts, ADHFE1 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADHFE1-associated genes across cancer lineages are eEF2, Tuberin, and EGFR_pY1068. Each is linked with ADHFE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADHFE1-to-partner and partner-to-ADHFE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ADHFE1-low versus ADHFE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADHFE1→partner) and Y-score (partner→ADHFE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.331	+1.807	.025	.027	3	2
UCEC	Tuberin →	+0.370	+3.469	<.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.229	-2.321	.027	.034	3	1
UCEC	FoxM1 →	+0.257	+2.321	.016	.006	3	1
UCEC	Gab2 →	+0.408	+1.807	.005	.027	3	1
UCEC	Heregulin →	-0.142	-2.700	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by ADHFE1 expression — UCEC

Explore this box plot interactively →