Across TCGA cell cohorts, ADH7 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADH7-associated genes across cancer lineages are GFRA4, CHIA, and KLRF1. Each is linked with ADH7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH7-to-partner and partner-to-ADH7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH7→partner) and Y-score (partner→ADH7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GFRA4 →	+0.025	+3.345	<.001	.007	3	1
LARGE_INTESTINE	CHIA →	+0.041	+3.345	<.001	.007	3	1
LARGE_INTESTINE	KLRF1 →	+0.915	+3.554	<.001	.007	3	1
LARGE_INTESTINE	BMP3 →	+0.498	+3.684	.001	.009	3	1
LARGE_INTESTINE	ACSM6 →	+0.027	+4.584	<.001	<.001	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

Exploration

ADH7 survival (RNA) · tumor vs normal (RNA) · all ADH7 data types