ADH6

Across TCGA patient cohorts, ADH6 mutation is significantly associated with the RNA expression of many other genes, with 989 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADH6-associated genes across cancer lineages are RNA5SP407, MIR373, and TRAJ29. Each is linked with ADH6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH6-to-partner and partner-to-ADH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP407 grouped by ADH6-low versus ADH6-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH6→partner) and Y-score (partner→ADH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP407 →	+0.238	+7.954	<.001	.008	3	2
CESC	MIR373 →	+0.516	+7.164	<.001	<.001	3	2
CESC	TRAJ29 →	+0.536	+5.010	<.001	.009	3	2
UCEC	NCAPH2 →	+0.601	+2.662	<.001	<.001	3	2
UCEC	ITGAE →	+0.433	+3.721	<.001	<.001	3	2
CESC	GNG10P1 →	+0.204	+5.306	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 989 associations by consensus.

RNA5SP407 by ADH6 expression — HNSC

Explore this box plot interactively →