ADH6

Across TCGA patient cohorts, ADH6 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADH6-associated genes across cancer lineages are C-Raf, GAPDH, and MEK1. Each is linked with ADH6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH6-to-partner and partner-to-ADH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ADH6-low versus ADH6-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH6→partner) and Y-score (partner→ADH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	C-Raf →	+0.422	+2.820	<.001	.035	3	2
SKCM	GAPDH →	+0.555	+2.000	.034	.031	3	2
UCEC	MEK1 →	+0.467	+2.415	.001	.003	3	2
UCEC	STAT3_pY705 →	-0.410	-2.222	<.001	.009	3	2
UCEC	Bak →	+0.224	+1.906	.026	.016	3	2
UCEC	Caspase-7-cleavedD198 →	+0.618	+3.479	.009	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

C-Raf by ADH6 expression — BLCA

Explore this box plot interactively →