ADH6

Across TCGA cell cohorts, ADH6 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADH6-associated genes across cancer lineages are ECE2, FAM153B, and TAFA1. Each is linked with ADH6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH6-to-partner and partner-to-ADH6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECE2 grouped by ADH6-low versus ADH6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH6→partner) and Y-score (partner→ADH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.205	+2.791	.004	.005	3	1
LARGE_INTESTINE	FAM153B →	+0.512	+3.648	<.001	.002	3	1
LARGE_INTESTINE	TAFA1 →	+0.205	+2.688	.004	.008	3	1
SKIN	TRIM64B →	+0.126	+4.125	<.001	.003	3	1
SKIN	TRIM64 →	+0.020	+4.437	<.001	.004	3	1
SKIN	LRRC3C →	+0.035	+4.054	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ECE2 by ADH6 expression — LARGE_INTESTINE

Explore this box plot interactively →