Across TCGA patient cohorts, ADH5 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADH5-associated genes across cancer lineages are S6_pS240_S244, EGFR_pY1068, and Notch1. Each is linked with ADH5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH5-to-partner and partner-to-ADH5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH5→partner) and Y-score (partner→ADH5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	S6_pS240_S244 →	+0.508	+3.169	.022	.020	3	2
UCEC	EGFR_pY1068 →	-0.347	-3.169	.011	.020	3	1
UCEC	Notch1 →	+0.216	+2.817	.005	.036	3	1
UCEC	AR →	-0.538	-3.169	.008	.020	3	1
UCEC	Tuberin_pT1462 →	+0.348	+3.009	.006	.019	3	1
UCEC	Tuberin →	+0.325	+3.169	.028	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

ADH5 survival (RNA) · tumor vs normal (RNA) · all ADH5 data types