Across TCGA patient cohorts, ADH4 mutation is significantly associated with the RNA expression of many other genes, with 1,908 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADH4-associated genes across cancer lineages are NPAT, OXSM, and VTI1A. Each is linked with ADH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH4-to-partner and partner-to-ADH4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH4→partner) and Y-score (partner→ADH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NPAT →	+0.607	+3.467	.001	.002	3	2
SKCM	OXSM →	+0.483	+2.353	<.001	.003	3	2
UCEC	VTI1A →	+0.399	+3.928	.005	<.001	3	2
SKCM	DPH3 →	+0.597	+3.070	.001	<.001	3	2
UCEC	FAM126B →	+0.457	+3.906	.002	<.001	3	2
UCEC	SUPV3L1 →	+0.546	+3.917	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,908 associations by consensus.

Exploration

ADH4 survival (RNA) · tumor vs normal (RNA) · all ADH4 data types