Across TCGA patient cohorts, ADH4 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADH4-associated genes across cancer lineages are MEK1, p62 Lck ligand, and PCNA. Each is linked with ADH4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH4-to-partner and partner-to-ADH4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH4→partner) and Y-score (partner→ADH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.455	+3.584	.009	.002	3	1
UCEC	p62 Lck ligand →	+0.432	+2.459	.005	.020	3	1
UCEC	PCNA →	+0.308	+2.459	.003	.020	3	1
UCEC	S6_pS240_S244 →	+0.484	+3.000	.013	.036	3	1
UCEC	ATM →	-0.497	-2.459	.023	.020	3	1
UCEC	Caspase-8 →	-0.302	-2.432	.012	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

ADH4 survival (RNA) · tumor vs normal (RNA) · all ADH4 data types