Across TCGA cell cohorts, ADH4 mutation is significantly associated with the mutation status of many other genes, with 972 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADH4-associated genes across cancer lineages are SEC63, TTI1, and CNTN3. Each is linked with ADH4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADH4-to-partner and partner-to-ADH4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH4→partner) and Y-score (partner→ADH4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEC63 →	+3.087	+4.392	.005	.005	1	3
BLOOD_Lymphoma	TTI1 →	+6.169	+6.169	<.001	<.001	1	3
BLOOD_Lymphoma	CNTN3 →	+6.169	+6.169	<.001	<.001	1	3
BLOOD_Lymphoma	PCDHA1 →	+4.169	+5.316	<.001	<.001	1	2
BLOOD_Lymphoma	CUX1 →	+3.169	+4.601	.003	.003	1	2
BLOOD_Lymphoma	AGT →	+4.584	+4.584	.007	.007	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 972 associations by consensus.

Exploration

ADH4 survival (RNA) · tumor vs normal (RNA) · all ADH4 data types