ADH1C

Across TCGA patient cohorts, ADH1C mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADH1C-associated genes across cancer lineages are eIF4E, FoxM1, and Rb_pS807_S811. Each is linked with ADH1C in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH1C-to-partner and partner-to-ADH1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ADH1C-low versus ADH1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH1C→partner) and Y-score (partner→ADH1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.165	+2.820	.037	.035	3	2
UCEC	FoxM1 →	+0.222	+2.662	.022	<.001	3	2
SKCM	Rb_pS807_S811 →	+0.400	+2.115	.003	.015	3	1
SKCM	Src →	-0.239	-2.058	.001	<.001	3	1
SKCM	Transglutaminase →	-0.137	-2.415	.015	.003	3	1
SKCM	Caveolin-1 →	-0.475	-1.765	.016	.012	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

eIF4E by ADH1C expression — UCEC

Explore this box plot interactively →