Across TCGA patient cohorts, ADH1A mutation is significantly associated with the RNA expression of many other genes, with 1,936 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADH1A-associated genes across cancer lineages are KCNK5, ADCY1, and ZNF467. Each is linked with ADH1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH1A-to-partner and partner-to-ADH1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH1A→partner) and Y-score (partner→ADH1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCNK5 →	-1.008	-2.785	<.001	.003	3	2
SKCM	ADCY1 →	+0.799	+1.650	.009	.002	3	2
SKCM	ZNF467 →	-0.572	-2.293	.001	.001	3	2
SKCM	TINCR →	+0.700	+1.954	.008	.002	3	2
UCEC	DHRS11 →	+0.617	+3.732	<.001	<.001	3	2
UCEC	FAF1 →	+0.377	+3.721	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,936 associations by consensus.

Exploration

ADH1A survival (RNA) · tumor vs normal (RNA) · all ADH1A data types