Across TCGA patient cohorts, ADH1A mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADH1A-associated genes across cancer lineages are GAPDH, mTOR_pS2448, and PCNA. Each is linked with ADH1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH1A-to-partner and partner-to-ADH1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH1A→partner) and Y-score (partner→ADH1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GAPDH →	+0.543	+2.115	.008	.017	3	2
UCEC	mTOR_pS2448 →	-0.157	-3.308	.010	.009	3	2
UCEC	PCNA →	+0.202	+1.807	.023	.027	3	2
UCEC	PRDX1 →	+0.238	+2.459	.005	.019	3	2
UCEC	TFRC →	+0.639	+1.807	.003	.027	3	2
UCEC	ATM →	-0.374	-1.807	.046	.027	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Exploration

ADH1A survival (RNA) · tumor vs normal (RNA) · all ADH1A data types