Across TCGA cell cohorts, ADH1A mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADH1A-associated genes across cancer lineages are FCN2, MRAP, and OR8B4. Each is linked with ADH1A in more than 1 cancer types. Because this analysis shows association rather than direction, both ADH1A-to-partner and partner-to-ADH1A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADH1A→partner) and Y-score (partner→ADH1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	FCN2 →	+0.036	+4.437	<.001	.004	3	1
SKIN	MRAP →	+0.020	+3.930	.006	.003	3	1
CNS	OR8B4 →	+0.045	+5.357	<.001	.001	3	1
LUNG_SCLC	LCN1 →	+0.529	+5.029	<.001	.006	3	1
LUNG_SCLC	SPATA31A5 →	+0.013	+5.029	<.001	.006	3	1
LARGE_INTESTINE	LILRA1 →	+0.013	+4.095	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

ADH1A survival (RNA) · tumor vs normal (RNA) · all ADH1A data types