ADGRL4

Across TCGA pan-cancer cohorts, ADGRL4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ADGRL4 data layer compared with 21 for mass-spec protein and 13 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ADGRL4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ADGRL4 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and HNSC show a favorable association.

CCRCC, UCEC, and HNSC are the cancer types where ADGRL4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.841	0.257	<.001	45	view →
UCEC	DFS	Quartile	III,IV	0.208	1.000	.013	22	view →
HNSC	DFS	Median	IV	0.793	0.510	.032	4	view →
LUAD	DFS	Tertile	All	0.822	0.964	.013	4	view →
LSCC	DFS	Quartile	All	0.823	0.953	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ADGRL4–CCRCC (DFS)

Open the CCRCC breakdown →