ADGRL4

Across TCGA patient cohorts, ADGRL4 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRL4-associated genes across cancer lineages are PCNA, eEF2, and p70-S6K_pT389. Each is linked with ADGRL4 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRL4-to-partner and partner-to-ADGRL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by ADGRL4-low versus ADGRL4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRL4→partner) and Y-score (partner→ADGRL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.283	+2.815	.038	.036	3	3
UCEC	eEF2 →	+0.398	+3.087	<.001	<.001	3	3
UCEC	p70-S6K_pT389 →	-0.203	-2.321	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.503	+1.945	.004	.002	3	3
UCEC	4E-BP1 →	+0.308	+3.087	<.001	<.001	3	3
UCEC	Cyclin-B1 →	+0.633	+2.584	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

PCNA by ADGRL4 expression — COAD

Explore this box plot interactively →