ADGRL2

Across TCGA patient cohorts, ADGRL2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,170 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ADGRL2-associated genes across cancer lineages are FHL5, HEYL, and CDH6. Each is linked with ADGRL2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ADGRL2-to-partner and partner-to-ADGRL2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ADGRL2 versus FHL5 in PDAC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRL2→partner) and Y-score (partner→ADGRL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	FHL5 →	+0.902	+0.313	<.001	<.001	3	5
CCRCC	HEYL →	+1.076	+0.286	<.001	<.001	3	5
LSCC	CDH6 →	+1.021	+0.283	.002	<.001	3	4
GBM	PCDH17 →	+0.615	+0.434	.009	.001	3	4
GBM	MYCT1 →	+0.792	+0.512	<.001	<.001	3	4
BRCA	RHOJ →	+0.764	+0.334	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,170 associations by consensus.

ADGRL2 vs FHL5 — PDAC

Explore this scatter interactively →