ADGRL2

Across TCGA patient cohorts, ADGRL2 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRL2-associated genes across cancer lineages are Caspase-7-cleavedD198, GAPDH, and FoxM1. Each is linked with ADGRL2 in more than 5 cancer types. Because this analysis shows association rather than direction, both ADGRL2-to-partner and partner-to-ADGRL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ADGRL2-low versus ADGRL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRL2→partner) and Y-score (partner→ADGRL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.557	+1.671	<.001	.003	3	6
BLCA	GAPDH →	+0.573	+3.169	.003	.017	3	4
LUAD	FoxM1 →	+0.330	+2.472	<.001	.010	3	4
UCEC	ACC1 →	+0.225	+1.205	.024	.049	3	4
UCEC	mTOR_pS2448 →	-0.105	-1.571	.010	.007	3	4
UCEC	PCNA →	+0.257	+1.722	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

Caspase-7-cleavedD198 by ADGRL2 expression — UCEC

Explore this box plot interactively →