ADGRL2

Across TCGA cell cohorts, ADGRL2 mutation is significantly associated with the RNA expression of many other genes, with 1,054 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADGRL2-associated genes across cancer lineages are ATG4C, LRRC40, and NANOS2. Each is linked with ADGRL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRL2-to-partner and partner-to-ADGRL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATG4C grouped by ADGRL2-low versus ADGRL2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRL2→partner) and Y-score (partner→ADGRL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ATG4C →	+0.587	+2.949	<.001	<.001	3	3
LARGE_INTESTINE	LRRC40 →	+0.529	+2.265	.001	.001	3	3
PANCREAS	NANOS2 →	+0.019	+4.491	<.001	.003	3	2
LARGE_INTESTINE	HSCB →	+0.597	+2.949	<.001	<.001	3	2
LARGE_INTESTINE	MAPK8 →	+0.583	+3.321	.004	.003	3	2
LARGE_INTESTINE	FRG1 →	+0.349	+2.459	.006	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,054 associations by consensus.

ATG4C by ADGRL2 expression — LARGE_INTESTINE

Explore this box plot interactively →