ADGRG7

Across TCGA patient cohorts, ADGRG7 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRG7-associated genes across cancer lineages are Notch1, TSC1, and ASNS. Each is linked with ADGRG7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRG7-to-partner and partner-to-ADGRG7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ADGRG7-low versus ADGRG7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG7→partner) and Y-score (partner→ADGRG7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.169	+2.100	<.001	.002	3	2
UCEC	TSC1 →	-0.147	-1.463	.003	.026	3	2
UCEC	ASNS →	+0.315	+1.247	.003	.041	3	2
UCEC	ATM →	-0.657	-2.050	<.001	<.001	3	2
UCEC	Bak →	+0.155	+1.184	.037	.022	3	2
UCEC	Caspase-8 →	-0.239	-3.365	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Notch1 by ADGRG7 expression — UCEC

Explore this box plot interactively →