ADGRG5

Across TCGA patient cohorts, ADGRG5 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRG5-associated genes across cancer lineages are ATM, Cyclin-B1, and ERK2. Each is linked with ADGRG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRG5-to-partner and partner-to-ADGRG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ADGRG5-low versus ADGRG5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG5→partner) and Y-score (partner→ADGRG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.596	-2.000	.003	.032	3	2
UCEC	Cyclin-B1 →	+0.517	+3.000	.041	.036	3	2
UCEC	ERK2 →	+0.318	+3.321	<.001	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.231	-3.459	.002	.005	3	1
UCEC	JNK2 →	+0.199	+2.000	.026	.032	3	1
UCEC	MSH2 →	-0.294	-3.312	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

ATM by ADGRG5 expression — UCEC

Explore this box plot interactively →