ADGRG5

Across TCGA cell cohorts, ADGRG5 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRG5-associated genes across cancer lineages are HELT and OR4F5. Each is linked with ADGRG5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRG5-to-partner and partner-to-ADGRG5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELT grouped by ADGRG5-low versus ADGRG5-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG5→partner) and Y-score (partner→ADGRG5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	HELT →	+0.041	+5.321	<.001	.005	3	1
LARGE_INTESTINE	OR4F5 →	+0.018	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

HELT by ADGRG5 expression — CNS

Explore this box plot interactively →