ADGRG4

Across TCGA pan-cancer cohorts, ADGRG4 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated ADGRG4 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ADGRG4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ADGRG4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UCEC, THYM, and LGG are the cancer types where ADGRG4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.833	0.604	<.001	36	view →
THYM	OS	Median	All	0.534	0.968	<.001	24	view →
LGG	DFS	Median	All	0.427	0.836	<.001	14	view →
ACC	OS	Median	All	0.158	0.632	.012	9	view →
SKCM	DFS	Median	II,III,IV	0.801	0.638	.008	9	view →
KIRC	DFS	Median	All	0.193	0.628	.012	8	view →
BRCA	DFS	Median	All	0.826	0.950	.004	6	view →
LIHC	OS	Median	III,IV	0.059	0.738	<.001	6	view →
LAML	DFS	Median	All	1.000	0.358	.049	4	view →
SARC	DFS	Median	All	0.159	0.594	.019	3	view →
LUAD	OS	Median	II,III,IV	0.350	0.564	.033	2	view →
SCLC	DFS	Median	All	1.000	0.481	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

ADGRG4–UCEC (DFS)

Open the UCEC breakdown →