Across TCGA pan-cancer cohorts, ADGRG3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ADGRG3 data layer compared with 21 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ADGRG3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ADGRG3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

PDAC, LSCC, and HNSC are the cancer types where ADGRG3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.441	0.961	.002	48	view →
LSCC	DFS	Quartile	III,IV	1.000	0.593	.042	1	view →
HNSC	OS	Median	IV	0.934	0.614	.047	1	view →
GBM	OS	Median	All	0.270	0.630	.031	1	view →
LUAD	DFS	Quartile	All	0.555	1.000	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ADGRG3 tumor-vs-normal RNA expression · all ADGRG3 data types