Across TCGA patient cohorts, ADGRG3 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRG3-associated genes across cancer lineages are mTOR_pS2448, PCNA, and INPP4B. Each is linked with ADGRG3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRG3-to-partner and partner-to-ADGRG3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG3→partner) and Y-score (partner→ADGRG3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.146	-2.980	.042	.036	3	2
UCEC	PCNA →	+0.326	+3.584	.001	.002	3	2
UCEC	INPP4B →	-0.354	-3.000	.023	.036	2	2
UCEC	JNK_pT183_Y185 →	-0.183	-3.000	.024	.036	3	1
UCEC	MSH2 →	-0.305	-3.143	.006	.018	3	1
UCEC	Notch1 →	+0.257	+3.183	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

Exploration

ADGRG3 survival (RNA) · tumor vs normal (RNA) · all ADGRG3 data types