Across TCGA patient cohorts, ADGRG1 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRG1-associated genes across cancer lineages are eEF2, MSH6, and VHL. Each is linked with ADGRG1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRG1-to-partner and partner-to-ADGRG1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRG1→partner) and Y-score (partner→ADGRG1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.327	+2.999	.019	.035	3	2
UCEC	MSH6 →	-0.460	-2.000	<.001	.029	3	2
UCEC	VHL →	-1.118	-2.222	<.001	.010	3	2
UCEC	c-Met_pY1235 →	+0.083	+2.502	.004	.002	3	2
UCEC	Cyclin-E2 →	+0.130	+1.884	.049	.030	3	2
UCEC	14-3-3_beta →	-0.081	-2.295	.040	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

Exploration

ADGRG1 survival (RNA) · tumor vs normal (RNA) · all ADGRG1 data types