ADGRF5

Across TCGA cell cohorts, ADGRF5 mutation is significantly associated with the RNA expression of many other genes, with 114 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ADGRF5-associated genes across cancer lineages are CTC1, KCNA1, and G6PC. Each is linked with ADGRF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRF5-to-partner and partner-to-ADGRF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTC1 grouped by ADGRF5-low versus ADGRF5-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRF5→partner) and Y-score (partner→ADGRF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CTC1 →	+0.508	+3.125	.001	.008	3	2
BLOOD_Myeloma	KCNA1 →	+0.022	+4.038	<.001	<.001	3	1
BLOOD_Myeloma	G6PC →	+0.023	+4.643	<.001	<.001	3	1
BLOOD_Myeloma	HS3ST6 →	+0.029	+3.000	<.001	.007	3	1
BLOOD_Myeloma	EMCN →	+0.056	+3.169	.001	.004	3	1
BLOOD_Myeloma	AMER3 →	+0.062	+3.781	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 114 associations by consensus.

CTC1 by ADGRF5 expression — SKIN

Explore this box plot interactively →