ADGRF3

Across TCGA patient cohorts, ADGRF3 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRF3-associated genes across cancer lineages are Annexin-1, Caspase-7-cleavedD198, and MEK1_p_S217_S221. Each is linked with ADGRF3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRF3-to-partner and partner-to-ADGRF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by ADGRF3-low versus ADGRF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRF3→partner) and Y-score (partner→ADGRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.554	+2.999	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.903	+2.115	<.001	<.001	3	3
SKCM	MEK1_p_S217_S221 →	+0.232	+2.000	.027	.031	3	3
UCEC	MEK1 →	+0.232	+1.137	.044	.041	3	2
UCEC	p62 Lck ligand →	+0.321	+2.999	.001	<.001	3	2
UCEC	PCNA →	+0.185	+2.115	.006	.016	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Annexin-1 by ADGRF3 expression — UCEC

Explore this box plot interactively →