ADGRF3

Across TCGA cell cohorts, ADGRF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,140 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ADGRF3-associated GO terms across cancer lineages are Negative regulation of RNA splicing, Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, and Regulation of G1/S transition of mitotic cell cycle. Each is linked with ADGRF3 in more than 11 cancer types. Because this analysis shows association rather than direction, both ADGRF3-to-partner and partner-to-ADGRF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of RNA splicing grouped by ADGRF3-low versus ADGRF3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRF3→partner) and Y-score (partner→ADGRF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of RNA splicing →	+0.104	+0.303	<.001	<.001	3	12
SOFT_TISSUE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.135	+0.279	<.001	<.001	3	11
BREAST	Regulation of G1/S transition of mitotic cell cycle →	+0.081	+0.328	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA splicing, via spliceosome →	+0.114	+0.382	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mRNA processing →	+0.109	+0.382	<.001	<.001	2	12
BREAST	Nuclear export →	+0.090	+0.328	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,140 associations by consensus.

Negative regulation of RNA splicing by ADGRF3 expression — BREAST

Explore this box plot interactively →