ADGRF2

Across TCGA patient cohorts, ADGRF2 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRF2-associated genes across cancer lineages are ERK2, FoxM1, and IGFBP2. Each is linked with ADGRF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRF2-to-partner and partner-to-ADGRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ADGRF2-low versus ADGRF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRF2→partner) and Y-score (partner→ADGRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.210	+2.000	.002	.009	3	3
UCEC	FoxM1 →	+0.190	+1.847	.045	.008	3	3
SKCM	IGFBP2 →	-0.505	-2.807	.011	.003	3	2
UCEC	p62 Lck ligand →	+0.423	+2.916	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.392	-2.321	<.001	.005	3	2
SKCM	STAT5a →	+0.435	+2.186	.044	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ERK2 by ADGRF2 expression — UCEC

Explore this box plot interactively →