ADGRF2

Across TCGA cell cohorts, ADGRF2 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ADGRF2-associated genes across cancer lineages are MC2R, LUZP4, and CARD18. Each is linked with ADGRF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRF2-to-partner and partner-to-ADGRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MC2R grouped by ADGRF2-low versus ADGRF2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRF2→partner) and Y-score (partner→ADGRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MC2R →	+0.018	+3.584	<.001	.003	3	2
LUNG_SCLC	LUZP4 →	+0.671	+3.459	.003	.003	3	2
SOFT_TISSUE	CARD18 →	+0.643	+5.369	<.001	.004	3	1
PANCREAS	NPBWR2 →	+0.023	+5.000	<.001	.006	3	1
PANCREAS	HMGB4 →	+0.015	+5.000	.008	.006	3	1
PANCREAS	KRTAP20-2 →	+0.126	+5.614	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

MC2R by ADGRF2 expression — LUNG_SCLC

Explore this box plot interactively →