ADGRE3

Across TCGA patient cohorts, ADGRE3 mutation is significantly associated with the RNA expression of many other genes, with 1,886 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ADGRE3-associated genes across cancer lineages are UFD1, LBX2, and KRT18P60. Each is linked with ADGRE3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ADGRE3-to-partner and partner-to-ADGRE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UFD1 grouped by ADGRE3-low versus ADGRE3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRE3→partner) and Y-score (partner→ADGRE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UFD1 →	+0.390	+3.024	<.001	<.001	3	3
SKCM	LBX2 →	+0.495	+2.832	.006	.001	3	3
SKCM	KRT18P60 →	+0.037	+1.711	<.001	<.001	3	3
LUSC	RN7SL822P →	+0.097	+3.811	<.001	.002	3	3
COAD	MIR8053 →	+0.490	+5.721	<.001	<.001	3	3
UCEC	DOC2B →	-1.089	-2.700	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,886 associations by consensus.

UFD1 by ADGRE3 expression — UCEC

Explore this box plot interactively →