ADGRE3

Across TCGA patient cohorts, ADGRE3 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ADGRE3-associated genes across cancer lineages are PEA-15_pS116, Src, and Src_pY527. Each is linked with ADGRE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRE3-to-partner and partner-to-ADGRE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PEA-15_pS116 grouped by ADGRE3-low versus ADGRE3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRE3→partner) and Y-score (partner→ADGRE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PEA-15_pS116 →	+0.278	+2.000	.008	.027	3	2
SKCM	Src →	-0.269	-1.925	.001	.004	3	2
LUSC	Src_pY527 →	+0.562	+2.816	.011	.036	3	1
SKCM	eIF4E →	+0.158	+3.169	.012	.017	3	1
SKCM	AMPK_alpha →	+0.144	+2.321	.004	.001	3	1
SKCM	PTEN →	+0.355	+2.415	.010	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

PEA-15_pS116 by ADGRE3 expression — SKCM

Explore this box plot interactively →