ADGRE3

Across TCGA cell cohorts, ADGRE3 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible ADGRE3-associated genes across cancer lineages are SCGB3A1, OR4D11, and TGIF2LY. Each is linked with ADGRE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both ADGRE3-to-partner and partner-to-ADGRE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB3A1 grouped by ADGRE3-low versus ADGRE3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRE3→partner) and Y-score (partner→ADGRE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	SCGB3A1 →	+0.208	+2.925	.001	.007	3	2
SKIN	OR4D11 →	+0.018	+3.700	<.001	.009	3	1
SKIN	TGIF2LY →	+0.202	+2.925	<.001	.007	3	1
SKIN	SFTPA2 →	+0.063	+2.845	.001	.009	3	1
SKIN	TEX35 →	+0.322	+3.617	.002	.004	3	1
SKIN	RBMY1B →	+0.467	+3.562	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

SCGB3A1 by ADGRE3 expression — SKIN

Explore this box plot interactively →