ADGRE1

Across TCGA patient cohorts, ADGRE1 mutation is significantly associated with the RNA expression of many other genes, with 4,334 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ADGRE1-associated genes across cancer lineages are PSMA6, GOLGA2P10, and TLR8. Each is linked with ADGRE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ADGRE1-to-partner and partner-to-ADGRE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMA6 grouped by ADGRE1-low versus ADGRE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ADGRE1→partner) and Y-score (partner→ADGRE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMA6 →	+0.419	+1.946	.002	<.001	3	4
UCEC	GOLGA2P10 →	+0.615	+2.153	<.001	<.001	3	3
COAD	TLR8 →	+0.652	+3.332	.006	.005	3	3
SKCM	ITGB1BP1 →	+0.364	+1.317	<.001	<.001	3	3
UCEC	ZWINT →	+0.745	+2.938	<.001	<.001	3	3
COAD	RTN4IP1 →	+0.515	+3.469	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,334 associations by consensus.

PSMA6 by ADGRE1 expression — UCEC

Explore this box plot interactively →